Endocrine Abstracts

Pituitary neuroendocrine tumors (PitNETs) are non-metastatic neoplasms of the pituitary that may overproduce hormones leading to systemic disorders or tumor mass effects causing headache, vertigo, or visual impairment. The overall estimated clinical prevalence of PitNETs is 1 in 400 to 1 in 1000 people. Although the pathogenesis of PitNETs has been extensively studied the molecular factors underlying tumorigenesis, remission, and therapy response of PitNETs are still unclear. ...

Introduction: Pituitary adenomas (PA) are tumours of the anterior pituitary. Despite the benign nature these neoplasms cause increased mortality and morbidity. Clinically relevant PAs affect around 0.1% of population during their lifetime. Currently, there is no human PA cell culture models. Tissue cultures derived from PA surgery materials depending on harvesting conditions can form free floating aggregates called pituispheres (PS) or adherent mesenchymal stromal cells (MSC)....

Objective: The most common type of pituitary diseases are pituitary adenomas (PA) of different origin. Although non-metastasizing, they still cause increased mortality and morbidity. Clinically significant PAs affect around 0.1% of population during lifetime. Circulating cell free DNA (ccfDNA) is approximately 165 bp long DNA fragments which are released in bloodstream upon cell death. ccfDNA has been used to investigate presence and properties of various cancers. Data on ccfD...